{"id":1895,"date":"2023-03-10T16:43:23","date_gmt":"2023-03-10T16:43:23","guid":{"rendered":"https:\/\/innotub.eu\/?p=1895"},"modified":"2023-08-28T10:52:57","modified_gmt":"2023-08-28T10:52:57","slug":"micobacteris-que-interfereixen-en-el-diagnostic-de-la-tuberculosi","status":"publish","type":"post","link":"https:\/\/innotub.eu\/ca\/micobacteris-que-interfereixen-en-el-diagnostic-de-la-tuberculosi\/","title":{"rendered":"Micobacteris que interfereixen en el diagn\u00f2stic de la tuberculosi"},"content":{"rendered":"\n

L'aparici\u00f3 d'animals en qu\u00e8 la infecci\u00f3 tuberculosa no es confirma per mitj\u00e0 de les t\u00e8cniques de laboratori, per\u00f2 que reaccionen de manera inespec\u00edfica a les tuberculines, representa un problema encara no resolt. Aix\u00f2 comporta el sacrifici d'animals que no estan realment infectats (falsos positius) i l'aplicaci\u00f3 de mesures restrictives sobre la granja d'origen. Aquestes reaccions poden ser degudes entre altres coses a una exposici\u00f3 pr\u00e8via dels animals a micobacteris no tuberculosos (MNT) o, encara que actualment no est\u00e0 perm\u00e8s en bovins, a l'\u00fas de vacunes davant de la tuberculosi o la paratuberculosi. Per aix\u00f2, un dels objectius que perseguim a INNOTUB \u00e9s identificar microorganismes no tuberculosos capa\u00e7os de provocar reaccions creuades en les proves de diagn\u00f2stic i caracteritzar-ne el grau d'interfer\u00e8ncia, cosa que permetr\u00e0 desenvolupar noves t\u00e8cniques o criteris de diagn\u00f2stic.<\/p>\n\n\n\n

D'aquesta manera, hem pogut demostrar en cobais que la majoria dels MNT estudiats poden induir reaccions creuades amb la tuberculina bovina i amb el reactiu P22, que la interpretaci\u00f3 comparada (utilitzant tamb\u00e9 tuberculina aviar) resoldria el problema en alguns casos i que el grau d'interfer\u00e8ncia pot dependre de la dosi de MNT a qu\u00e8 s'exposen els animals. Com a troballa positiva de l'estudi, cal destacar que nom\u00e9s els animals exposats a Mycobacterium bovis<\/em> i Mycobacterium caprae <\/em>(principals causants de la tuberculosi animal) van reaccionar als reactius PCL i FP, per la qual cosa podrien complementar la tuberculina bovina o fins i tot substituir-la en un futur. D'aquesta manera, l'especificitat de la prova de diagn\u00f2stic es veuria millorada, evitant l'aparici\u00f3 de falsos positius per\u00f2 sense perdre la capacitat d'identificar els animals realment infectats (sensibilitat).<\/p>\n\n\n\n

Aquest estudi, liderat per NEIKER, ha estat finan\u00e7at pels projectes INNOTUB (EFA359\/19\/INNOTUB, cofinan\u00e7at pel FEDER) i GoatTBfree (PID2019-105155RB-C33) i ha estat publicat a la revista Scientific Reports<\/em> i \u00e9s d'acc\u00e9s lliure al seg\u00fcent enlla\u00e7<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

L'aparici\u00f3 d'animals en qu\u00e8 la infecci\u00f3 tuberculosa no es confirma per mitj\u00e0...<\/p>\n","protected":false},"author":5,"featured_media":1902,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"yoast_head":"\nMicobacteris que interfereixen en el diagn\u00f2stic de la tuberculosi » Innotub<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innotub.eu\/ca\/micobacteris-que-interfereixen-en-el-diagnostic-de-la-tuberculosi\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Micobacteris que interfereixen en el diagn\u00f2stic de la tuberculosi » Innotub\" \/>\n<meta property=\"og:description\" content=\"L'aparici\u00f3 d'animals en qu\u00e8 la infecci\u00f3 tuberculosa no es 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