{"id":3003,"date":"2026-11-10T11:47:52","date_gmt":"2026-11-10T11:47:52","guid":{"rendered":"https:\/\/innotub.eu\/?p=3003"},"modified":"2026-11-10T11:53:19","modified_gmt":"2026-11-10T11:53:19","slug":"tres-candidats-a-vacunes-contra-la-tuberculosi-redueixen-les-lesions-i-la-carrega-bacteriana-en-cabres","status":"publish","type":"post","link":"https:\/\/innotub.eu\/ca\/tres-candidats-a-vacunes-contra-la-tuberculosi-redueixen-les-lesions-i-la-carrega-bacteriana-en-cabres\/","title":{"rendered":"Tres candidats a vacunes contra la tuberculosi redueixen les lesions i la c\u00e0rrega bacteriana en cabres"},"content":{"rendered":"\n<p>La vacunaci\u00f3 representa una eina prometedora per complementar els programes de control i eradicaci\u00f3 de la tuberculosi animal, especialment en regions on les estrat\u00e8gies basades en el diagn\u00f2stic i l'abatiment d'animals infectats no han aconseguit eliminar la malaltia o no s\u00f3n viables. No obstant aix\u00f2, perqu\u00e8 el seu \u00fas sigui factible, les vacunes no nom\u00e9s han de ser eficaces, sin\u00f3 tamb\u00e9 compatibles amb les t\u00e8cniques de diagn\u00f2stic.<\/p>\n\n\n\n<p>En un estudi anterior dut a terme per membres de la xarxa INNOTUB II, es va dur a terme una avaluaci\u00f3 preliminar de l'efic\u00e0cia i la interfer\u00e8ncia en el diagn\u00f2stic de diferents prototips en un model de ratol\u00ed. La investigaci\u00f3 va incloure una vacuna viva, vacunes basades en micobacteris inactivats per calor i altres inactivades per bacteri\u00f2fags; aquestes \u00faltimes estaven dissenyades per mantenir un perfil antigenic m\u00e9s similar al de les bact\u00e8ries vives que el que s'obt\u00e9 mitjan\u00e7ant el tractament t\u00e8rmic, que provoca una denaturaci\u00f3 incontrolada d'aquests ant\u00edgens. A partir dels resultats, alguns dels candidats m\u00e9s prometedors es van seleccionar per a una caracteritzaci\u00f3 m\u00e9s detallada del seu rendiment contra la tuberculosi en cabres infectades.<\/p>\n\n\n\n<p>En <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42800088\/\">aquest estudi, publicat recentment a la revista <em>Vaccine<\/em><\/a>, investigadors de NEIKER i IRTA-CReSA han investigat els efectes de tres candidats a vacuna sobre la progressi\u00f3 de la malaltia, la c\u00e0rrega bacteriana i la resposta immunit\u00e0ria en cabres infectades amb <em>Mycobacterium caprae<\/em>, centrant-se en la seva efic\u00e0cia protectora i la interfer\u00e8ncia en el diagn\u00f2stic. Les vacunes avaluades van ser una basada en <em>Mycobacterium bovis<\/em> inactivat per calor (HIMB), una altra basada en *M. caprae* inactivat per fagh\u00e0g (PIMC) i una vacuna viva de <em>Mycobacterium microti<\/em>\u00a0(LMM).<\/p>\n\n\n\n<p>La gravetat de les lesions totals es va reduir significativament en els animals vacunats en comparaci\u00f3 amb els animals infectats que no estaven immunitzats.  A m\u00e9s, algunes de les vacunes van induir efectes beneficiosos en altres par\u00e0metres associats a la progressi\u00f3 de la malaltia, com ara una reducci\u00f3 de la c\u00e0rrega bacteriana, el volum de les lesions als ganglis limf\u00e0tics afectats, la mineralitzaci\u00f3 del teixit pulmonar o la propagaci\u00f3 de la infecci\u00f3 m\u00e9s enll\u00e0 del lloc d'entrada del bacteri.<\/p>\n\n\n\n<p>L'altre aspecte clau per permetre l'\u00fas de vacunes en animals sotmesos a proves diagn\u00f2stiques de tuberculosi bovina \u00e9s evitar que provoquin interfer\u00e8ncies, \u00e9s a dir, reaccions creuades que donin falsos positius. Les tres candidatures de vacuna van mostrar una lleu interfer\u00e8ncia quan es va dur a terme la prova oficial, coneguda com a assaig de liberaci\u00f3 d'interfer\u00f3 gamma, utilitzant tuberculines convencionals. No obstant aix\u00f2, la vacunaci\u00f3 amb qualsevol d'elles va ser compatible amb aquesta mateixa t\u00e8cnica quan es van utilitzar ant\u00edgens definits dissenyats per a diferenciar els animals vacunats dels que estaven realment infectats, una estrat\u00e8gia coneguda com a DIVA (Differentiating Infected from Vaccinated Animals).<\/p>\n\n\n\n<p>Els resultats indiquen que la vacunaci\u00f3 amb qualsevol dels tres prototips avaluats ajuda a millorar la resposta a la infecci\u00f3 per M. caprae, tot i que els efectes van ser m\u00e9s pronunciats amb les vacunes HIMB i LMM. El prototip HIMB es va destacar per la seva capacitat per reduir la c\u00e0rrega bacteriana i potenciar la resposta immunit\u00e0ria innata, alhora que causava una interfer\u00e8ncia m\u00ednima en les proves de diagn\u00f2stic, especialment quan es van utilitzar reactius DIVA.<\/p>\n\n\n\n<p> Per la seva banda, la LMM va demostrar una excel\u00b7lent compatibilitat amb les estrat\u00e8gies de diagn\u00f2stic DIVA i una reducci\u00f3 notable de les lesions i la pres\u00e8ncia bacteriana, la qual cosa la converteix en una alternativa prometedora, malgrat les possibles preocupacions de bioseguretat, ja que no \u00e9s una vacuna inactivada. El prototip PIMC tamb\u00e9 va produir efectes positius en diversos dels par\u00e0metres analitzats, tot i que en menor mesura. No obstant aix\u00f2, aquesta primera versi\u00f3 encara t\u00e9 limitacions t\u00e8cniques relacionades amb la p\u00e8rdua de material antigenic durant el proc\u00e9s d'inactivaci\u00f3 del fagh, un aspecte que actualment s'est\u00e0 optimitzant. En general, els resultats obtinguts amb aquestes vacunes justifiquen estudis addicionals per explorar i consolidar la seva utilitat com a eines complement\u00e0ries en el control de la tuberculosi animal.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La vacunaci\u00f3 representa una eina prometedora per complementar els programes de control...<\/p>\n","protected":false},"author":4,"featured_media":3015,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,1],"tags":[],"class_list":["post-3003","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualitat","category-sense-categoria"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Tres candidats a vacunes contra la tuberculosi redueixen les lesions i la c\u00e0rrega bacteriana en cabres &#187; Innotub<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innotub.eu\/ca\/tres-candidats-a-vacunes-contra-la-tuberculosi-redueixen-les-lesions-i-la-carrega-bacteriana-en-cabres\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tres candidats a vacunes contra la tuberculosi redueixen les lesions i la c\u00e0rrega bacteriana en cabres &#187; 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