{"id":1911,"date":"2023-03-13T09:42:29","date_gmt":"2023-03-13T09:42:29","guid":{"rendered":"https:\/\/innotub.eu\/mycobacteries-qui-interferent-avec-le-diagnostic-de-la-tuberculose\/"},"modified":"2023-08-28T10:53:49","modified_gmt":"2023-08-28T10:53:49","slug":"mycobacteries-qui-interferent-avec-le-diagnostic-de-la-tuberculose","status":"publish","type":"post","link":"https:\/\/innotub.eu\/fr\/mycobacteries-qui-interferent-avec-le-diagnostic-de-la-tuberculose\/","title":{"rendered":"Mycobact\u00e9ries qui interf\u00e8rent avec le diagnostic de la tuberculose"},"content":{"rendered":"\n

La pr\u00e9sence d'animaux chez lesquels l'infection tuberculeuse n'est pas confirm\u00e9e par des techniques de laboratoire, mais qui r\u00e9agissent de mani\u00e8re non sp\u00e9cifique aux tuberculines, repr\u00e9sente un probl\u00e8me encore non r\u00e9solu. Cela conduit \u00e0 l'abattage d'animaux qui ne sont pas vraiment infect\u00e9s (faux positifs) et \u00e0 l'application de mesures restrictives dans l'\u00e9levage d'origine. Ces r\u00e9actions peuvent \u00eatre dues, entre autres, \u00e0 une exposition ant\u00e9rieure des animaux \u00e0 des mycobact\u00e9ries non tuberculeuses (MNT) ou, bien qu'actuellement interdites chez les bovins, \u00e0 l'utilisation de vaccins contre la tuberculose ou la paratuberculose. Pour cette raison, l'un des objectifs que nous poursuivons \u00e0 INNOTUB est d'identifier les micro-organismes non tuberculeux capables de provoquer des r\u00e9actions crois\u00e9es dans les tests de diagnostic et de caract\u00e9riser le degr\u00e9 d'interf\u00e9rence, ce qui permettra le d\u00e9veloppement de nouvelles techniques ou crit\u00e8res de diagnostic.<\/p>\n\n

De cette fa\u00e7on, nous avons pu d\u00e9montrer chez le cobaye que la plupart des MNT \u00e9tudi\u00e9s peuvent induire des r\u00e9actions crois\u00e9es avec la tuberculine bovine et avec le r\u00e9actif P22, que l'interpr\u00e9tation comparative (utilisant \u00e9galement la tuberculine aviaire) r\u00e9soudrait le probl\u00e8me dans certains cas et que le degr\u00e9 d'interf\u00e9rence peut d\u00e9pendre de la dose de MNT \u00e0 laquelle les animaux sont expos\u00e9s. Comme r\u00e9sultat positif de l'\u00e9tude, il convient de noter que seuls les animaux expos\u00e9s \u00e0 Mycobacterium bovis<\/em> et Mycobacterium caprae<\/em> (les principales causes de la tuberculose animale) ont r\u00e9agi aux r\u00e9actifs PCL et FP, afin qu'ils puissent compl\u00e9ter la tuberculine bovine ou remplacer la tuberculine bovine \u00e0 l'avenir. De cette mani\u00e8re, la sp\u00e9cificit\u00e9 du test de diagnostic serait am\u00e9lior\u00e9e, en \u00e9vitant l'apparition de faux positifs mais sans perdre la capacit\u00e9 d'identifier les animaux r\u00e9ellement infect\u00e9s (sensibilit\u00e9).<\/p>\n\n

Cette \u00e9tude, men\u00e9e par NEIKER, a \u00e9t\u00e9 publi\u00e9e dans la revue Scientific Reports et est librement accessible sur ce lien.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

La pr\u00e9sence d'animaux chez lesquels l'infection tuberculeuse n'est pas confirm\u00e9e par des...<\/p>\n","protected":false},"author":5,"featured_media":1905,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"yoast_head":"\nMycobact\u00e9ries qui interf\u00e8rent avec le diagnostic de la tuberculose » Innotub<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/innotub.eu\/fr\/mycobacteries-qui-interferent-avec-le-diagnostic-de-la-tuberculose\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mycobact\u00e9ries qui interf\u00e8rent avec le diagnostic de la tuberculose » Innotub\" \/>\n<meta property=\"og:description\" content=\"La pr\u00e9sence d'animaux chez lesquels l'infection 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